Etoposide is usually given daily for 35 days and courses should not be repeated more frequently than at intervals of 21 days. Oral treatment with etoposide in small cell lung cancer. Etoposide is an inhibitor of the enzyme topoisomerase ii, derived from podophyllum peltatum, the mayapple, a perennial herbaceous plant. Toposar etoposide dose, indications, adverse effects. In canada call your doctor for medical advice about side effects. Oral etoposide and palliative treatment for smallcell lung. Since the growth of normal body cells may also be affected by etoposide, other effects will also occur. It has significant therapeutic activity in childhood leukemia, testicular. Being an antineoplastic, it stops the cancer cells from undergoing. L1 cells, may be useful to study the mechanisms underlying the side effects of chemicals, including. Etoposide is used to treat testicular cancer and certain forms of lung cancer such as small cell lung cancer. Etoposide is used in combination with other drugs when all other treatment has failed for lung cancer and testicular tumors. Toxicological evaluation of the topoisomerase inhibitor. However, it seems to interfere with the growth of the cancer cells, which are eventually destroyed.
Etoposide by injection national library of medicine. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects. To further our understanding of the differences in the cellular responses to treatment with low compared to high concentrations of etoposide. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several. Talk to your doctor about the risks of using this medication for your condition. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to expect. Sep 18, 2008 our vepesid etoposide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Etoposide can be administered either as intravenous infusion or in oral form. They can include low blood cell counts, vomiting, loss of appetite, diarrhea, hair loss, and fever. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these. Oral etoposide and palliative treatment for smallcell. Doctors give trusted answers on uses, effects, side effects, and cautions. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. Etoposide may also be used for purposes not listed in this medication guide. For more information, see the drug information summary for etoposide phosphate. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects of the oral form. The exact way that etoposide acts against cancer is not known. There is no information regarding presence of etoposide in human milk or its effects on breastfed infant milk production. It is also used for hemophagocytic lymphohistiocytosis. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online web or by phone 18003321088.
Etoposide is a scheduledependent cytotoxic drug with high single agent activity in smallcell lung cancer and lymphoma. You may report side effects to the fda at 1800fda1088. The reproductive toxicity and abnormal nuclear morphological changes seemed to correlate with the adverse effects of etoposide. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate. In a multidrug regimen, each medication has unique side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The paper is an interim report on 339 patients randomised to receive oral etoposide 50 mg twice daily for 10 days or intravenous regimens, consisting of either etoposide and vincristine or cyclophosphamide, doxorubicin, and vincristine, depending on the treatment centre. Etoposide dosage and pharmacodynamics springerlink.
Etoposide injection also known as vp16 is used in combination with other cancer medicines to treat cancer of the testicles and small cell lung cancer. Etoposide induces cell death via mitochondrialdependent. You may report side effects to health canada at 18662342345. A preparation containing etoposide phosphate can be given by intravenous injection or infusion. These side effects may go away during treatment as your body adjusts to the medicine. Etopophos etoposide phosphate, also commonly known as vp16, is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat. Some side effects of etoposide may occur that usually do not need medical attention. Etoposide may be given orally or by slow intravenous infusion, the oral dose being double the intravenous dose. Etoposide is a topoisomerase ii inhibiting anticancer drug, derived from podophyllotoxin. Other side effects not listed may also occur in some patients. Bleomycin, etoposide, and cisplatin bep etoposide and carboplatin etoposide and. Interferon can cause many different types of sideeffects including anemia.
Etoposide is also available in a different form called etoposide phosphate. Etoposide intravenous route side effects mayo clinic. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. If these drugs are used together, closely monitor for increased side effects of etoposide, vp16. Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats article pdf available. Before taking etoposide, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. It is best to read this information with our general information about chemotherapy and the type of cancer you have. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of. The topoisomerase inhibitors camptothecin and etoposide. The effect of renal disease on plasma etoposide clearance is not known. Sep 19, 2019 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etopophos etoposide phosphate for injection, for intravenous use. Other severe side effects include allergic reactions and low blood.
Etopophos etoposide phosphate is available in an injection into the vein, but a different form of this medication etoposide. Download fulltext pdf download fulltext pdf combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma. Dec 31, 2019 the mean renal clearance of etoposide is 7 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 to 600 mgm 2. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Bleomycin, etoposide, and cisplatin bep etoposide and carboplatin etoposide and cisplatin ep. Speak to your care provider regarding the timing of laboratory tests to monitor your blood cell counts. There is a lot of evidence of its effectiveness and experience with what side effects you might have with this medication. In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have. Jan 01, 2017 etoposide belongs to the group of medicines known as antineoplastic agents.
The lowest goodrx price for the most common version of etoposide is around. Pdf combination of cyclophosphamide, etoposide, carboplatin. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular. Side effects of etopophos etoposide phosphate, warnings. Serious side effects bone marrow suppression is a decrease in the number of white blood cells, red blood cells, and platelets and can be severe with etoposide. It is used to treat small cell lung cancer and other cancers. Etoposide uses, side effects, substitutes, composition. Etoposide side effects, dosage, interactions drugs everyday. This is not a complete list of side effects and others may occur.
Doctors give trusted answers on uses, effects, sideeffects, and cautions. It has significant therapeutic activity in childhood leukemia, testicular tumors, hodgkins disease, large cell lymphomas and small cell lung cancer sclc. The paper is an interim report on 339 patients randomised to receive oral etoposide 50 mg twice daily for 10 days or intravenous regimens, consisting of either etoposide and vincristine or. Side effects of etopophos etoposide phosphate, warnings, uses. Nov 09, 2018 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etoposide works by slowing the growth of cancer cells. Etoposide, vp16 is a substrate for the drug transporter pglycoprotein pgp. Other severe side effects include allergic reactions and low blood pressure. Apr 19, 2016 the mean renal clearance of etoposide is 7 mlminm 2 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 mgm 2 to 600 mgm 2.
Vepesid etoposide chemotherapy, side effects navigating care. Interferon can cause many different types of side effects including anemia, low white blood cell counts, low platelet counts, decreased appetite, tiredness, fatigue and depression. If you notice any other effects, check with your healthcare professional. The topoisomerase inhibitors camptothecin and etoposide induce a cd95. Etoposide uses, side effects, substitutes, composition and. Etoposide belongs to the group of medicines known as antineoplastic agents. Etoposide oral vepesid side effects, medical uses, and. It is used by mouth or injection into a vein side effects. Apr 10, 2018 serious side effects bone marrow suppression is a decrease in the number of white blood cells, red blood cells, and platelets and can be severe with etoposide. After treatment with etoposide has ended, normal hair growth should return. Etoposide side effects, dosage, interactions drugs. May 21, 2019 etopophos etoposide phosphate, also commonly known as vp16, is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat cancer of the lung or testicles. Pdf effects of etoposide and cyclophosphamide acute.
It is also sometimes used to treat some other kinds of cancer in both males and females. In 100 people receiving cisplatin, etoposide, more than 20 and up to. In addition, low grade fever and muscle aches may occur. Etoposide and cisplatin chemotherapy, known as ep or sometimes pe, is used to treat several types of different cancer. Side effects not requiring immediate medical attention. Etoposide side effects, dosage, interactions drugs everyday health search. Possible side effects of cisplatin, etoposide table version date.
Etoposide increased the numbers of cells with subg1 dna content in a concentrationdependent manner. Etoposide by mouth national library of medicine pubmed. Etoposide can lower blood cells that help your body. Know etoposide uses, side effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on.
A preparation containing etoposide phosphate can be given by intravenous. Etoposide is a semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase ii and its function in ligating cleaved dna molecules, resulting in the accumulation of single or doublestrand dna breaks, the inhibition of dna replication and transcription. Call your doctor for medical advice about side effects. If you experience a serious side effect, you or your doctor may send a. Etoposide, sold under the brand name etopophos among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. Etoposide is in the topoisomerase inhibitor family of medication. Possessing potent antineoplastic properties, etoposide. Your doctor will talk to you about this treatment and its. Jan 26, 2020 side effects not requiring immediate medical attention.
Download fulltext pdf download fulltext pdf combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma patients. Etoposide can be administered either as intravenous. Despite its clear dosedependent myelosuppressive activity, dosedependent evidence of its antitumour activity is harder to demonstrate. Call your doctor if you have any unusual problems while taking this medication. In our previous studies we have investigated the role of mcl1 in dna damage response by using a low concentration of etoposide 17, 21. In clinical studies, the most commonly reported carboplatin plus etoposide drug side effects are shown here. Infection, especially when white blood cell count is low. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etoposide and cisplatin chemotherapy ep macmillan cancer. Etopophos etoposide phosphate has been on the market for over 30 years. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Etoposide, therefore, is cleared by both renal and nonrenal processes, i. Etoposide is used for small cell lung cancer, testicular cancer etc.
645 1232 41 1126 512 606 918 448 614 1549 176 1562 483 231 1450 531 532 1508 694 1202 1360 1160 1447 221 898 509 495 84 283 856 205 509 1179